Clinical and functional characterization of congenital or acquired digestive motility disorders
pseudoobstruction, achalasia, esophageal atresia, anorectal malformations, Hirschsprung disease
We have published one of the largest series of pediatric patients with intestinal pseudoobstruction and several other papers on functional (manometric studies) evaluation, genetic or etiopathogenic factors in congenital motility disorders.
We are currently conducting the characterization of esophageal motility patterns in achalasia in children.
We are also carrying out, starting in May 2015, a large study on genotyping (collaboration with Nicolas Pilon, PhD) and phenotyping with long-term outcome and assessement of quality of life of patients operated on for Hirschsprung disease.
We are also interested in acquired post surgical motility disorders such as esophageal atresia (using high resolution esophageal manometry we have described the abnormalities of esophageal motility associated with esophageal atresia), sequellae of anorectal malformations or postocclusive intestinal dysmotility.